Possibility of Whole Body Activation Autoradiography
نویسندگان
چکیده
منابع مشابه
The utilisation of Quantitative Whole Body Autoradiography (QWBA) methods to investigate whole body tissue distribution in the minipig
The choice of the correct species for toxicity testing of drug candidates being developed for human use is a critical one. Rodents are the commonly used 1 species and monkeys, pigs and dogs are the candidates available for the 2 species. These all have sufficient background data to be used in toxicology studies but the choice has to be made which is most appropriate and representative of the cl...
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The distribution of radiolabel in male mice was studied by autoradiography of whole-body cryosections at intervals during 24 h after i.v. injection (46.6 mg/kg) and during 4 h after oral administration (140 mg/kg) of [2-14C]merbarone. Following injection, radioactivity levels in the blood and highly vascular tissues declined to 8 h at which time only low levels were present in the systemic circ...
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Distribution of radioactive carbon from [U-14C]glucose in the mouse poisoned by hydrofluoric acid has been studied by whole-body autoradiography. Under normal conditions, the highest autoradiographic density was found in the Harder's gland, palatine gland, sublingual gland, large intestinal mucosa, and many regions of the central nervous system 30 minutes after intraperitoneal injection of [U-1...
متن کاملQuantitative whole-body autoradiography of radiolabeled antibody distribution in a xenografted human cancer model.
Quantitative whole-body autoradiography (WBAR) was used to study the biodistribution of goat anti-carcinoembryonic antigen and normal goat IgG, each labeled with 125I, in hamsters bearing the carcinoembryonic antigen-producing GW-39 human colonic carcinoma xenograft. Comparisons between computer-assisted videodensitometric profiles of WBARs and tissue radioactivity counts were made at 1, 3, and...
متن کاملUse of whole-body autoradiography in cancer targeting with radiolabeled antibodies.
Methods of single-tracer whole-body autoradiography (WBAR) have been developed in our laboratory which allow imaging and measurement of the zonal distribution of radioiodinated antibodies and their fragments within GW-39 colon carcinoma xenografts varying in size from large, cystic masses with necrotic cores to micrometastases. The whole-animal distribution of 90Y-labeled anti-carcinoembryonic ...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1970
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.19.11_511